Menu
Search
Advertising Disclosure

10 Best sinus medicines of 2025

Explore up to 28% off
  • Best Choice

    1

    GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness
    Clicked 138 times in the last month
    GenCare

    GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

    25% Off
    9.7
    Exceptional
    Our Rating
    More info
  • Curious about how we select the top products for you? Explore How It Works
  • Value for Money

    2

    Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2
    Vicks

    Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

    14% Off
    9.5
    Excellent
    Our Rating
    More info

  • 3

    Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets
    Mucinex

    Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets

    21% Off
    9.4
    Excellent
    More info

  • 4

    Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct
    Sudafed

    Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

    25% Off
    9.3
    Excellent
    Our Rating
    More info

  • 5

    Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct
    Tylenol

    Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

    26% Off
    9.0
    Excellent
    Our Rating
    More info
  • See Today’s Deals & Prices

  • 6

    Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
    Tylenol

    Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

    28% Off
    8.7
    Very Good
    More info

  • 7

    Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps
    Vicks

    Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

    8.6
    Very Good
    More info

  • 8

    Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct
    Sudafed

    Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

    26% Off
    8.5
    Good
    Our Rating
    More info

  • 9

    Benadryl Allergy Plus Congestion Ultratabs with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct
    Benadryl

    Benadryl Allergy Plus Congestion Ultratabs with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct

    19% Off
    8.3
    Good
    More info

  • 10

    Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct
    Sudafed

    Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct

    20% Off
    8.2
    Good
    Our Rating
    More info